Abstract: There is a strong coupling between the steam turbine body and the regenerative system, which makes it extremely difficult to calculate the due value of economic operation indicators of steam turbines online. This paper further analyzes the problems existing in the existing mathematical model for establishing the due value of steam turbine economic operation indicators by using the generalized linear regression method. The paper discusses the method of establishing the due value model of steam turbine operation economic indicators by using RBF network, and compares it with the conventional linear regression and nonlinear regression linear models. The results show that the RBF network model has a fast convergence speed and small error, providing an accurate and simple method for evaluating the economic performance of steam turbine operation.