Abstract: To enhance the stability and efficiency of copper-based catalysts in photothermal methanol reforming for hydrogen production, this study proposes a catalyst design strategy based on high-entropy principles. A six-component high-entropy two-dimensional Cu₂Zn₁Al₀.₅Ce₅Zr₀.₅In₀.₅O_x catalyst was successfully synthesized using a polyvinylpyrrolidone （PVP）-assisted freeze-drying method. Characterization techniques, including X-ray diffraction （XRD）, scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, and nitrogen adsorption-desorption analysis, confirmed the single-phase crystal structure and nanosheet morphology of the catalyst, along with its superior anti-sintering and anti-oxidation properties. In thermal catalytic reactions, the catalyst exhibited a hydrogen production rate of 1887.94 mmol/（g·h） at 450 °C. When integrated with a novel photothermal conversion device, the catalyst demonstrated remarkable photothermal catalytic activity under a solar intensity of 2 kW/m², achieving a methanol steam reforming hydrogen production rate of 1402.12 mmol/（g·h） while maintaining stability over 72 hours, indicating exceptional long-term durability.Further experiments revealed that the high performance of this catalyst is primarily attributed to the thermodynamic stability and unique porous structure derived from its high-entropy characteristics. These features significantly increased the number of catalytic active sites and enhanced resistance to high-temperature conditions. Compared to traditional catalysts, the six-component high-entropy Cu₂Zn₁Al₀.₅Ce₅Zr₀.₅In₀.₅O_x exhibited significantly improved catalytic performance and stability in photothermal methanol reforming for hydrogen production, addressing the sintering challenges caused by temperature fluctuations in outdoor photothermal systems. This study not only provides a novel and efficient catalyst design strategy for the photothermal catalysis field but also advances the practical application of high-entropy materials under complex reaction conditions. By integrating high-entropy materials with photothermal catalytic technology, this work offers theoretical support and practical solutions for the sustainable and efficient production of hydrogen energy, showcasing the broad industrial application potential of this catalyst in hydrogen production.