Abstract: Methanol is an important clean fuel and basic chemical raw material. There is an urgent need for large amounts of methanol green methanol and a huge market gap under the global energy transition and carbon neutrality situation. Therefore, there is an urgent need to break through the methanol synthesis technology. Currently, large-scale and stable synthesis of methanol through the “coal power carbon capture coupled with hydrotreating to methanol” (CPCC-HM) route already has a certain industrial foundation. However, the whole life-cycle carbon emission (WLCCE) of methanol prepared by this route is unknown. In addition, due to the large inconsistency in the maturi-ty of the green/low-carbon power utilization technology in different processes, various combinations of processes will be formed in the future as the technology progresses. Nevertheless, WLCCE of methanol synthesized under different combinations has not been reported. In this work, based on the maturity of green technologies in different processes, the combination and integration of CPCC-HM route is carried out, and WLCCE of methanol is accounted for all combinations. In the traditional scenario where fossil energy is used to supply the energy of coal-powered carbon capture, compressed hydrogen, synthesized methanol and transported methanol, the WLCCE of methanol is 1.193 tCO2/tCH3OH. It meets China's standards for low-carbon methanol and represents a feasible technological pathway for the low-carbon transition of traditional methanol. The WLCCE of methanol is 0.650 tCO2/tCH3OH when the steam required for coal-powered carbon capture and the synthesized methanol is generated by green power, which meets China's clean methanol standards and demonstrates significant low-carbon benefits. The WLCCE of the synthesized metha-nol is 0.329 tCO2/tCH3OH when the energy required for coal-powered carbon capture, compressed hydrogen, and methanol synthesis is supplied by green power, which meets both China's renewable methanol standards and the green methanol criteria of the EU's Renewable Energy Directive. Based on the results, CPCC-HM route is very promising for large-scale green methanol synthesis. Finally, the recommendations for the development of CPCC-HM route were proposed. This study has significance for the development of green methanol in China, and favors to drive the energy transition and achieve the “dual carbon” target.