Abstract: A waste incineration power generation project with a processing capacity of 1200 tons/day and a power generation capacity of 20 MW in northern Henan province was conducted. In order to improve the operation level and economic benefits, through experimental data analysis, the optimal operation mode of the cold end and feed pump in different seasons and different working conditions is found and applied to the daily intelligent optimization control of the power plant, so as to finally achieve the purpose of reducing the power consumption rate of the plant and improving the economic benefits of waste incineration power generation. This study provides a research direction for the development of China's waste-to-energy industry.