Abstract: Zero discharge of desulfurization wastewater is the key content of waste water management in thermal power plants. Cement solidification technology has potential as the final disposal means of zero discharge. The cement solidification technology has simple process, stable performance and wide application. In order to further optimize the application of cement immobilization technology in high concentration FGD wastewater treatment, durability research experiments were conducted based on the existing FGD wastewater flue gas concentration and cement curing technology. The compressive strength of the cured body was used as the basis for investigating the curing effect. Firstly, the curing body was made by mixing the FGD wastewater with cement, fly ash and river sand, and the compressive strength was tested after curing to a specific age. The orthogonal experiment was designed by controlling univariate method to investigate the effects of water-cement ratio, cement-ash ratio and river sand amount on the compressive strength of the cured body. The results show that the water-cement ratio has a significant effect on the compressive strength of concrete. The key to the selection of the curing composition ratio is the water-cement ratio, which leads to a decrease in the compressive strength of the cured body if the water-cement ratio increases. The water-cement ratio is controlled at 0.4-0.6. When the mud-cement ratio reaches 3.2∶1.0,the compressive strength performance of the cured body reaches the best state; and the change in the amount of river sand has less effect on the compressive strength of the cured body. At the same time, the leaching rate of heavy metal ions was analyzed to prove the feasibility of the curing method. The research provides basic data for the cement fixation of high salinity desulfurization wastewater.