Abstract: In order to develop the low cost hydrophobically modified polyacrylamide( HMPAM) and to solve the problem of efficient treatment of industrial wastewater,the synthesis of hydrophobically modified polyacrylamides was discussed in this paper.HMPAM,as an important branch of hydrophobic associating water-soluble polymers,has the characteristics of viscosity enhancement,salt resistance and shear resistance.HMPAM synthesis methods such as co-solvent method,micellar copolymerization method,emulsion polymerization method,free radical interfacial polymerization method,ultrasonic polymerization method and supercritical CO_2 polymerization method were also analyzed.Clearly,various synthesis methods have long R & D production cycle and high cost.Besides,the synthesis efficiency is low and the treatment effect is poor.By combining computational simulation technology with experimental results,a more scientific,rapid and low-cost HMPAM synthesis method is proposed by perfecting the system of synthesis monomer and synthesis method.